In addition, the inhibition effect of the Akt/mTOR/p70S6K pathway by carbon ions was superior to that of X-rays at the same dose, indicating that the prominent superiority of carbon ions over X-rays in killing both breast cancer cell lines might result from the inhibition of the Akt/mTOR/p70S6K pathway. The gene discussed is AKT1; the disease is breast carcinoma.