Moreover, the patients with high FDG-uptake were significantly associated with the progression of tumour size, T factor, lymphatic invasion, venous invasion, stage, the high expression of HIF1-A and GLUT1 and the low expression of CD8, PD-L1 and E-cadherin compared to those with low FDG-uptake (Table 1). Here, SLC2A1 is linked to neoplasm.