Specifically, variants from seven genes (ACTG1, ATP1A3, COCH, MYO7A, NF2, NLRP3, and TMC1) exerted their pathogenic effect as either AD inheritance or de novo occurrence of the AD gene whereas, causative variants from following seven genes (TMPRSS3, CDH23, GJB2, ILDR1, MYO15A, SERPINB6, and SLC26A4) were always associated with AR inheritance for manifestation of the deafness phenotype in post-lingually deafened subjects. The gene discussed is SERPINB6; the disease is Alzheimer disease.