CD101, which is next to PTGFRN (150 kb downstream from rs146978188), is reported to be expressed on macrophages/monocytes and T-cells, to confer a modulatory/coregulatory function, and to be conspicuously downregulated in rheumatoid arthritis patients.37 Because macrophages are a chief contributor to gouty attack, CD101 might be the true susceptible gene for normal type gout. This evidence concerns the gene PTGFRN and gout.