Combined type gout displayed the following seven significant loci (table 2): rs74904971 of ABCG2 (pmeta=1.53×10–56; OR=2.46), rs116873087 of NAA25 (pmeta=1.88×10–27; OR=2.38), rs3775948 of SLC2A9 (pmeta=1.43×10–19; OR=1.67), rs6586063 of SHLD2/FAM35A (pmeta=4.30×10–11; OR=1.49), rs9905274 of BCAS3 (pmeta=5.62×10–9; OR=1.37), rs11231879 of CDC42BPG (pmeta=7.66×10–10; OR=1.44) and rs1260326 of GCKR (pmeta=1.05×10–8; OR=1.37). This evidence concerns the gene SHLD2 and gout.