Some of the most striking odds of disease are seen with autoimmune conditions such as the association between ankylosing spondylitis and possession of HLA-B*27 (odds ratio >100) or between Behçet’s Disease and HLA-B*51 (accounts for 32–50% of cases) (Matzaraki et al., 2017; de Menthon et al., 2009). This evidence concerns the gene HLA-B and ankylosing spondylitis.