Spock3 and Timp4, encode proteins that participate in inhibiting matrix metalloproteinases (MMPs) involved in the degradation of the extracellular matrix [52], and the other genes encode proteins that inhibit lipoteichoic acid-induced NF-κB, MAP kinase, and Akt activities [53] and decrease the invasion and metastasis of tumor cells in the brain [54]. The gene discussed is TIMP4; the disease is neoplasm.