Age-up genes in astrocytes, C4b, involved in synapse elimination [48]; Snca and Sncg, 2 genes related to Parkinson’s disease pathogenesis [49] that also play several roles in synaptic activity, such as regulation of synaptic-vesicle trafficking and subsequent neurotransmitter release [50, 51], suggesting that astrocytes play a critical role in synapse elimination and synaptic transmission. This evidence concerns the gene SNCA and Parkinson disease.