We analysed the expression of 232 AAGs in 497 LUAD and 54 non-tumour tissues using the Wilcoxon signed-rank test in R, and 30 AAGs were eventually identified using the criteria of |log2FC| > 1 and FDR < 0.05, including 12 downregulated genes (NRG3, DLC1, NLRC4, HSPB8, DAPK2, PPP1R15A, FOS, NRG1, PRKCQ, CCL2, GRID1, MAP1LC3C) and 18 upregulated genes (HSPA5, ERBB2, PARP1, P4HB, IKBKE, BNIP3, ATIC, IFNG, VMP1, ITGB4, EIF4EBP1, PTK6, GAPDH, ATG9B, ERO1A, TMEM74, CDKN2A, BIRC5) (Fig. 1). This evidence concerns the gene NRG1 and neoplasm.