EGFR and non-small cell lung carcinoma: EGFR (ErbB1) is not unknown to us; in 2004, there was a major discovery that treatment with the EGFR-TKI (epidermal growth factor receptor-tyrosine kinase inhibitor) gefitinib caused tumour regression in some patients with NSCLC [44], and the third-generation EGFR-TKI axitinib confers greater survival benefits to patients, particularly those with the T790M mutation [45].