In colon and rectal carcinoma (CRC), KRAS is also found predominantly in a mutated isoform (45 %), whereas NRAS mutations are infrequent (in 7.5 % of CRC) and HRAS mutations have not been detected.4 RAS proteins act as molecular switches alternating between an active, GTP‐bound state and an inactive, GDP‐bound state. The gene discussed is NRAS; the disease is colorectal carcinoma.