PNPLA2 and obesity due to melanocortin 4 receptor deficiency: When CGI‐58 was knocked down in adult animals with antisense oligonucleotides (ASOs), liver TGs were raised 4‐fold,(19) and mice were protected against diet‐induced obesity (DIO), despite the presence of hepatic steatosis.(19) Collectively these findings suggest that pharmacological inhibition of ATGL and/or stimulation of PPARα signaling may have beneficial metabolic effects.