PNPLA3 and hepatocellular carcinoma: Evidence highlighted the possible interaction between PNPLA3 and CGI‐58 in hepatocytes.(7) In detail, co‐immunoprecipitation and pulldown experiments in hepatoma cells (HuH7) and mouse livers demonstrated that PNPLA3 I148M sequestrates CGI‐58, thus impeding its interaction with ATGL and therefore preventing LD depletion.