In the liver, Atgl−/− mice show an enriched hepatic pool of oleic acid, which in turn prevented against pharmacologically induced (tunicamycin) ER stress.(14) Ong et al.(15) showed that ATGL deficiency leads to hepatic steatosis, concomitantly enhancing glucose tolerance and hepatic glucose use. Here, PNPLA2 is linked to Hepatic steatosis.