Importantly, the PNPLA3 I148M genetic variant creates a strong predisposition to developing nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) toward steatohepatitis, fibrosis/cirrhosis, and liver cancer.(29) This genetic variant consists of one single‐base polymorphism, where a cytosine (C) is substituted with a guanine (G), leading to a different amino acid sequence in the translated protein (methionine instead of isoleucine at residue 148). Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.