In addition, lipophagy also facilitates the catabolism of cytoplasmic lipid‐droplet (LD) components to lysosomes for subsequent degradation by lysosomal enzymes.(3) Lysosomal acid lipase also plays a crucial role in lipoprotein lipid catabolism and hydrolyzes cholesteryl esters and TGs in the cell.(4) In humans, loss‐of‐function mutations of the lipase A gene cause rare lysosomal disorders, such as Wolman disease.(4). The gene discussed is LIPA; the disease is Wolman disease.