In APP/PSEN1 mice, PTEN-regulated cognitive impairment presents as increased synaptic long-term depression, which is ameliorated by inhibition of PTEN with VO-OHpic, or the synthetic peptide PTEN-PDZ, which disrupts the binding of PTEN to PSD-95 [28]. The gene discussed is PSEN1; the disease is Cognitive impairment.