By the introduction of c-MYC, an important oncogene in human hepatocellular carcinomas (HCCs), into the organoids derived from transdifferentiated hepatocytes, Sun et al. (2020) observed excessive contacts between the mitochondria and the endoplasmic reticulum membranes, which appeared to be an unrecognized oncogenic event in liver carcinogenesis (Sun et al., 2019). Here, MYC is linked to hepatocellular carcinoma.