Zibadi Zibadi S S Cordova Cordova F F Slack Slack EH EH Watson Watson RR RR Larson Larson DF DF Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling Leptin’s regulation of obesity-induced cardiac extracellular matrix remodeling Cardiovasc Toxicol Cardiovasc Toxicol 2011 2011 11 11 4 4 325 325 333 333 21744298 21744298. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.