(11) showed that BACH2 dysregulation is directly involved in T1DM pathogenesis since inhibition of this gene caused cytokine-induced apoptosis of human and rodent beta-cells through activation of the JNK1/BIM pathway and anti-apoptotic members of the BCL-2 family, whereas BACH2 overexpression protected these cells against apoptosis (11). Here, BCL2 is linked to type 1 diabetes mellitus.