We used qRT–PCR analysis to examine the effect of narciclasine on the expression of four known MYC target genes TERT, SLC19A1, MYB and PMM2. Narciclasine treatment induced a significant reduction in expression of all four MYC target genes in both BC-1 and BC-3 cell lines (Fig. 4B). Here, TERT is linked to breast cancer.