CRLF2 and acute lymphoblastic leukemia: The same group also developed an 8-gene assay (JCHAIN, SPATS2L, CA6, NRXN3, MUC4, CRLF2, ADGRF1, BMPR1B) to identify Ph-like ALL with targetable kinase gene aberrations [32] and generated an integrated score between 0 and 1, with a score of ≥ 0.5 being predictive of Ph-like ALL.