Nuclear factor kappa-light-chain-enhancer of activated B cells (NFΚB) signaling pathway is believed to be a link between inflammation and cancer, due to the induction of proliferation, blocking apoptosis in cells and maintaining angiogenesis [3], and the induction of oxidative stress with hypoxia inducible factor 1 alpha (HIF-1α) and estrogen receptor β (ERβ) [4]. The gene discussed is ESR2; the disease is cancer.