SOD1 and posterior cortical atrophy: We observed that the blocking of NFΚB resulted in increased ROS production and DNA damage in both PCa cell lines, and was associated with cell cycle arrest in the G2/M cell cycle phase and the modulation of SOD-1 and HIF-1α expression in LNCaP and DU-145 cell lines, although the changes in the expression were different for those two cell lines.