For example, d-limonene decreased NO levels in Aβ42-expressing fly heads [48], and linalool reduced the levels of the pro-inflammatory markers p38 MAPK, NOS2, COX2 and IL-1β in the brain of a triple transgenic mouse model of Alzheimer’s disease (3xTg-AD) [73]. Here, PTGS2 is linked to Alzheimer disease.