Our results suggest that the synergistic effect exerted by the combination of RP4010 with gemcitabine and nab-paclitaxel on the proliferation of pancreatic cancer cells was mediated through the downregulation of calcium regulated pro-survival signaling pathways, such as Akt/mTOR and NFAT/NF-kB signaling. Here, NFKB1 is linked to familial pancreatic carcinoma.