Several studies have demonstrated the critical role of the CRAC channel components, Orai1 and STIM1, in the proliferation, apoptosis resistance, invasion, and metastasis of various cancer types, including cervical cancer [6], breast cancer [7,8], prostate cancer [9], glioblastoma [10,11], esophageal cell carcinoma [12], hepatocellular carcinoma [13], as well as PDAC [14]. Here, ORAI1 is linked to cancer.