Since RP4010 inhibited cancer cell proliferation and colony formation through the inhibition of calcium-regulated Akt/mTOR and NFAT/NF-κB signaling, we further tested whether RP4010 could enhance the anticancer activities of gemcitabine and nab-paclitaxel, which are commonly used for the treatment of pancreatic cancer. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.