As shown in Figure S1, the IC50 of RP4010 for ORAI1 knocked down cells (siORAI1) increased by almost 76% as compared with the control cells (32.89 μM vs. 18.7 μM), indicating that the effect of RP4010 on the proliferation of pancreatic cancer cells mainly stems from its ability to inhibit CRAC channel. Here, ORAI1 is linked to familial pancreatic carcinoma.