The hyperphosphorylation of p62/SQSTM1 and downstream Nrf2-antioxidant axis was recently shown to promote metabolic reprogramming to enhance the chemoresistance of hepatocellular carcinoma (HCC) cells [452], and to enhance the diethylnitrosamine (DEN) carcinogenic activity for HCC development [453]. This evidence concerns the gene SQSTM1 and hepatocellular carcinoma.