SQSTM1 and cholangiocarcinoma: To date, whether mitophagy is altered and how mitophagy participates in the development of cholangiocarcinoma remain largely unknown, although p62/SQSTM1-mediated mitophagy and regulation of mitochondrial dynamics were shown to sensitize cholangiocarcinoma cells to the cytotoxic effects of the chemotherapeutic drug cisplatin [558].