According to another study conducted in mice, diet-induced NAFLD suppresses the completion of mitophagy and leads to the accumulation of mitophagy intermediates, e.g., megamitochondria that contain p62/SQSTM1, Kelch-like ECH-associated protein (Keap1), and ubiquitin (Table 3) [537]. This evidence concerns the gene SQSTM1 and metabolic dysfunction-associated steatotic liver disease.