Beyond serological testing for Hp-I, there are further diagnostic modalities used for the investigation of a possible association between Hp-I and NAFLD: Urea breath test [18,19,20,21,22,23] and the detection of Hp antigen in patients’ stool [24] for the diagnosis of Hp-I, as well as sonography [10,19,23,24,25,26], and liver function tests and various noninvasive indices [10,11,22,27] for the diagnosis of NAFLD. This evidence concerns the gene HP and metabolic dysfunction-associated steatotic liver disease.