When Langer et al. performed a similar study to investigate the potential link between CYP2R1, VDBP, and DHCR7 genotypes and the risk of HCV-related HCC development by using 1279 HCV-related HCC patients, they found a functionally relevant role for VD in the prevention of HCV-related HCC [44]. This evidence concerns the gene CYP2R1 and hepatocellular carcinoma.