CYP2R1 and hepatocellular carcinoma: When Barooach et al. determined whether VDR, VDBP, and CYP2R1 gene polymorphisms are risk factors for clinical complications in HCV-related HCC patients, they identified the VDR ApaI CC genotype and the VDR bAt haplotype as independent predictors for cirrhosis and HCC development in HCV patients [77].