DAPK1, a Ca2+/CaM-dependent serine/threonine protein kinase, plays a critical role in death signaling (proapoptotic, apoptotic and autophagic pathways) and the regulation of internal and external stress-induced cell damage, including ischemia and Aβ [124,125,126], which implies that it may have a role in various neuropathologies, such as AD, ischemia, and epilepsy. This evidence concerns the gene DAPK1 and Alzheimer disease.