Moreover, the p.K687Q mutation in APP is a likely pathogenic variant in AD, according to the standards of the American College of Medical Genetics and Genomics (ACMG) [39], while the other mutation (p.D244G) and two mutations (p.T297M and p.D332G), which were previously not associated with AD, remain uncertain with respect to their significance in the pathogenesis of AD [39]. Here, APP is linked to Alzheimer disease.