Today, more than 50 mutations in APP have been found to cause AD, and most of the pathogenic mutations are clustered in exons 16 and 17 of APP (around cleavage sites for α-, β-, and γ-secretases, especially γ-secretases), such as p.K687N [36] and p.M722K (Table 1) [37]. The gene discussed is APP; the disease is Alzheimer disease.