Consistent with this, knocking down USP26 could decrease AR and/or ARv7 protein stability in EnzS1-C4-2, EnzR1-C4-2, and EnzR3-CWR22Rv1 PCa cells (Figure 6A–C), likely due to increasing ubiquitination of AR in EnzS1-C4-2 (Figure 6D,E) and EnzR1-C4-2 cells (Figure 6F,G). This evidence concerns the gene USP26 and posterior cortical atrophy.