The results revealed that inhibition of BCL2 activity by ABT263 (with and without Enz treatment) resulted in cleaved-PARP expression in EnzS1-C4-2, EnzR1-C4-2, and EnzR3-CWR22Rv1 PCa cells, suggesting that ABT263 could promote PCa apoptosis (Supplementary Figure S4A). This evidence concerns the gene BCL2 and posterior cortical atrophy.