USP26 and posterior cortical atrophy: To determine the critical role of USP26 in Enz sensitivity in PCa cells, we applied MTT proliferation assay in response to Enz treatment and found that knocking down USP26 itself could not only increase Enz sensitivity (9.8% in EnzS1-C4-2, 10.6% in EnzR1-C4-2, and 13.2% in EnzR3-CWR22Rv1 cells), but also partly reverse the sensitivity increase by ABT263 (Figure 5E–G, right panels) in EnzS1-C4-2 (E), EnzR1-C4-2 (F), and EnzR3-CWR22Rv1 (G) cells.