Jeon et al. showed that CD8+ T cells close to sensory neurons latently infected with HHV-1 expressed markers of immune activation, which indicated that lymphocytes come into contact with low levels of viral antigens during latency [18].Our study found that the percentage of CD3+ and CD4+ T cells co-expressing the CD25 activation antigen was higher in patients with reactivated herpes infections than in the control group. Here, CD4 is linked to Herpesviridae infectious disease.