The Cox regression test indicated that low-level autophagy gene set expression and the signature that combines low-level IMPA2 and autophagy gene set expression, but not low-level IMPA2 expression alone, served as independent risk factors in the multivariate analysis, even though all of them appear to be poor prognostic markers for estimating an unfavorable outcome in the univariate analysis of TCGA ccRCC patients (Figure 6E). The gene discussed is IMPA2; the disease is nonpapillary renal cell carcinoma.