According to the stratification using IMPA2 levels in a Kaplan–Meier analysis against TCGA ccRCC patients in our previous report, here we performed Pearson’s test to examine the coexpression of the IMPA2 transcript with other somatic genes in either metastatic ccRCC with low-level IMPA2 or nonmetastatic ccRCC with high-level IMPA2 to ascertain the possible mechanism by which IMPA2 downregulation promotes ccRCC metastasis (Figure 1A). This evidence concerns the gene IMPA2 and nonpapillary renal cell carcinoma.