Accordingly, the transcriptional profiling of IMPA2 and the autophagy gene set obtained from hallmark gene sets of Molecular Signatures Database (https://www.gsea-msigdb.org/gsea/msigdb) showed a significant (p = 0.0049) positive correlation in RCC cell lines from the Cancer Cell Line Encyclopedia database (Figure 3C). The gene discussed is IMPA2; the disease is cancer.