Furthermore, the Cox regression analysis indicated that low-level IMPA2 expression and the signature that combines low-level IMPA2 and high-level mTORC1 gene set expression, but not high-level mTORC1 gene set expression alone, act as independent risk factors in the multivariate analysis, even though all of them appear to be poor prognostic markers for predicting an unfavorable outcome in the univariate analysis of TCGA ccRCC patients in the univariate analysis (Table S1). The gene discussed is IMPA2; the disease is nonpapillary renal cell carcinoma.