A recent study showed that a treatment with a rapamycin analog inhibitor of mTOR, temsirolimus (CCI779), significantly induced CD133 expression in liver CSCs and human HCC cells, and combination treatment with a flavonoid baicalein and temsirolimus eliminated chemoresistance to mTOR inhibition in liver CSCs and the patient-derived xenograft model of HCC. The gene discussed is PROM1; the disease is hepatocellular carcinoma.