Over the last few years, several case-controls studies have indicated that monoallelic FANCM [7,8,9,10,11,12,13,14,15] truncating mutations are breast cancer risk factors; in addition, there are inconsistent results regarding FANCA [16,17,18,19], FANCC [20,21,22,23,24], SLX4 [25,26,27] and XRCC2 [28,29,30]. This evidence concerns the gene FANCM and breast cancer.