A prospective cohort of 1021 unrelated cancer cases with clinical suspicion of hereditary cancer was screened for mutations in the following 14 FA genes: FANCA, FANCB, FANCC, FANCD2, FANCE, FANCF, FANCG/XRCC9, FANCI, FANCL/PHF9, FANCM, FANCP/SLX4, FANCQ/ERCC4, FANCR/RAD51 and FANCU/XRCC2. This evidence concerns the gene SLX4 and hereditary cancer.