FANCA and Hereditary breast and ovarian cancer syndrome: Apart from conditions caused by biallelic mutations in FA genes, it is well known that monoallelic mutations in certain FA genes (BRCA1, BRCA2, BRIP1, PALB2 and RAD51C) are clearly related with hereditary breast and/or ovarian cancer predisposition [6], and these genes are bona-fide hereditary breast and ovarian cancer (HBOC) predisposition genes.