HRH3 and memory impairment: Furthermore, statistical analysis showed that chronic pretreatment with H3R antagonist E177 (5 and 10 mg/kg, i.p.)significantly counteracted the memory impairment of PTZ-kindled animals by significantly decreasing TLT, with [F(1,10) = 14.20; P < 0.05] and [F(1,10) = 10.82; P < 0.05], respectively, and as compared with PTZ-kindled rats, and no significant difference was observed in the procognitive effect provided by H3R antagonist E177 (5 and 10 mg/kg), with [F(1,10) = 1.47; P = 0.25] (Figure 3A).