HRH3 and memory impairment: Furthermore, statistical analysis revealed that chronic systemic pretreatment with H3R antagonist E177 (5 and 10 mg/kg, i.p.)significantly counteracted the memory impairment induced in PTZ-kindled rats, with [F(1,10) = 14.24; P < 0.05] and [F(1,10) = 6.87; P < 0.05], respectively, and as compared with PTZ-kindled rats (Figure 2A).