HRH3 and Cognitive impairment: Therefore, the findings suggest the potential of H3R antagonist E177 as adjuvant to currently available AEDs with an added advantage of preventing cognitive impairment, highlighting the histaminergic system as a potential therapeutic target for the therapeutic management of epilepsy with accompanied memory deficits, although further seizure test models with different animal species are still warranted to corroborate and expand these initial data.