The results of in vitro and in vivo studies suggest that SoB can modulate the expression of enzymes involved in the synthesis of melatonin, e.g., AANAT and HIOMT [19,44,45], and may even lead to an elevation in melatonin concentration in the small intestinal tissue as well as Mtr1a expression in the liver of mice with fructose-induced NAFLD [19]. Here, AANAT is linked to metabolic dysfunction-associated steatotic liver disease.