Boussetta et al. [91] demonstrated that PUA exerts a potent anti-inflammatory effect through inhibition of TNF-α-induced priming of NADPH oxidase by attacking p38MAPKinase / Ser345-p47phox-axis and releasing myeloperoxidase in a rat model of 2, 4, 6- trinitrobenzenesulfonic acid (TNBS) induced colitis. Here, TNF is linked to colitis.