The MDA-MB-436 cell line was established from a metastatic breast cancer patient with a BRCA1 mutation at nt5396 leading to a truncated protein, and another cell line was HCC1937, which was derived from a patient with TNM (Tumor, Node, Metastasis) stage IIB primary cancer with the BRCA1 mutation at nt5832insC resulting in a frameshift change (ATCC® TCP-1003). The gene discussed is BRCA1; the disease is neoplasm.