The aim of this study was to identify and evaluate the possible association between the expression of certain SNPs of CD16A and CD32A genes alongside systemic and local immune responses in ABDs, with a focus on rs396991 of the CD16A gene and rs1801274 of the CD32A gene in pemphigus and SABDs. The gene discussed is FCGR3A; the disease is human HOXA1 syndromes.