FCGR3A and pemphigus: We postulate that rs396991 (CD16A polymorphism) may be of greater importance in ABD development, where (i) the genotype CA (rs396991) is probably associated with the complement activation pathway in SABDs (p = 0.0078; Chi-square test), and (ii) the genotype AA (rs396991) is probably associated with the IgG1-mediated response (chronic stage of disease) in pemphigus (p = 0.0121; Chi-square test).