Two missense variants were identified within the non-helical head (amino-teminal) domain of desmin, i.e., in P1 with biventricular form of ACM (NM_001927.3: c.127A > G; NP_001918.3: p.(K43E)) and in P2 with DCM (NM_001927.3: c.170C > T; NP_001918.3: p.(S57L)) (Figure 1, Tables S2 and S3). Here, DES is linked to familial dilated cardiomyopathy.