GJA1 and Seizure: Based on these clinical and preclinical findings, to explore the pathomechanisms and pathophysiology of ADSHE seizure associated with Cx43 induced by S284L-mutant α4β2-nAChR, the present study determined the effects of the subchronic administration of a therapeutic-relevant dose of ZNS on functional abnormality of transmission in the focus region (M2C) and the thalamocortical motor pathway associated with Cx43 and α4β2-nAChR of S286L-TG.