PTGS2 and colorectal carcinoma: This process in the CRC cells involves multiple molecular targets including enzymes (cyclooxygenase-2 (COX 2)), transcription factors (NF-kB and beta-catenin), Bcl-2 family members (Bcl-2, Bax, and Bcl-xL), death receptors (death receptor 5 (DR5) and Fas), protease enzymes (caspase 3 and caspase 8), and ROS.