BCL2 and colon adenocarcinoma: It has been shown that curcumin promotes Bax expression and reduces Bcl-2 in colon adenocarcinoma all through the phosphorylation at Ser15 and activation of p53 [35] Enhanced Bax expression could influence Bcl-2/Bax or Bcl-xL ratio, thus driving neoplastic cells to apoptosis.