HSPA5 and prion disease: In particular, in the “prion diseases” pathway, our analysis identified significantly higher levels of Complement Component 1, q Subcomponent, B Chain (C1QB), Heat Shock Protein Family A Member 5 (HSPA5), Proto-Oncogene Tyrosine-Protein kinase Fyn (FYN), Laminin Subunit Gamma 1 (LAMC1) and ETS Like-1 Protein (ELK1) and significantly lower levels of Mitogen-Activated Protein Kinase 1 (MAP2K1) (Figure 2).