In this sense, Takagi and colleagues demonstrated that falcarinol restored FoxO1 and increased C/EBPα levels (transcription factors that positively regulate adiponectin gene transcription), resulting in HMW adiponectin secretion by 3T3-L1 adipocytes treated with palmitic acid, an obesity model in vitro [295]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.