In multiple cancers, including adult T-cell leukemia/lymphoma, diffuse large B-cell lymphoma, and stomach adenocarcinoma, the presence of structural variations leads to shortening of programmed cell death ligand 1 (PD-L1) 3′ UTR, causing the marked elevation of aberrant PD-L1 transcripts due to enhanced mRNA stabilization [117]. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.