FOXP3 and colitis: Briefly, the inhibition of class I HDACs in models of cardiac allograft transplantation (CAT) or colitis has shown an enhanced Treg function following HDAC2 deletion, thus preventing HDAC2 association with Foxp3 [153,154], whereas the blockage of HDAC1, 3, and 8 has been shown to provoke an attenuated Treg number and function by destabilizing Foxp3 [152,153,155,156].