Therefore, their role in Treg cell differentiation is mainly characterized by a Foxp3 destabilizing effect in murine sepsis (cecal-ligation and puncture), heterotrophic cardiac and orthotropic renal allograft transplantation, colitis [55,87,126,160,169,170,171,180], and by preventing Foxp3 expression in a mouse model of transient middle cerebral artery occlusion [173]. The gene discussed is FOXP3; the disease is colitis.