The results revealed 3 high-risk immune genes, namely Prostaglandin D2 Synthase (PTGDS), Alpha-2-Macroglobulin (A2M), and Sphingosine-1-Phosphate Receptor 1 (S1PR1), as well as 2 TFs, Forkhead Box P3 (FOXP3) and Endothelial PAS Domain Protein 1(EPAS1), with strong association to prognosis of CRC. This evidence concerns the gene EPAS1 and colorectal carcinoma.