In fact, expression of their receptors including C-X-C Motif Chemokine Receptor 4 (CXCR4) and C-C Motif Chemokine Receptor 6 (CCR6), has been proposed as a potential predictor of CRC recurrence, poor survival, and liver metastasis [27, 28]. Here, CXCR4 is linked to colorectal carcinoma.