As shown in Fig 3A, tumors generated from U2OS cells with CDKL3 knockdown was ∼2-fold smaller than that of the control group, along with the significant difference of tumor weight between them (0.180 ± 0.008g versus 0.361 ± 0.033g, ***P < 0.001) (Fig 3B). Here, CDKL3 is linked to neoplasm.