5 This potentially indicates that alcohol is of more influence as a cause of an elevated AST/ALT ratio in men than in women. There was no significant association between AST/ALT ratio ≥2 and the presence of an elevated GPR score, predicting fibrosis (p=0.2; data not shown). We calculated PAR as a way to assess the relative contribution of different risk factors to the overall burden of liver disease; table 3. The gene discussed is GPT; the disease is liver disorder.