Abnormal LFTs are common in HIV infection for diverse reasons including direct cytopathic effects of HIV on hepatocytes, coinfection with other BBVs, opportunistic infection, malignancy, antiretroviral therapy (ART) or other drugs, or secondary to other factors such as alcoholism.41–44 Although a proportion of our study population with fibrosis were infected with BBV (21.6%) and/or had a history of alcohol consumption (12.2%), there was a residual proportion with scores suggestive of fibrosis and AST/ALT ratio >2 who cannot be accounted for through either alcohol or BBV infection. This evidence concerns the gene GPT and HIV infectious disease.