N.T. is a 6-month-old infant, born at full term with a normal perinatality. At 15 days of life he was referred to our Center for positive neonatal screening for Cystic Fibrosis (CF) with two F508del CFTR mutations. The positive result of the sweat test (Chloride 64 mEq/L) confirmed the diagnosis and at the age of 17 days he was taken in charge by our CF Center of Brescia. Here, CFTR is linked to cystic fibrosis.