The authors suggested that TIMP upregulation with latanoprost acid might possibly occur to compensate for the increase in MMPs.69 In contrast, in a study using 6 different TM cell strains isolated from human donor eyes, exposure for 24 h to a high concentration of bimatoprost caused increased expression of mRNA for MMP-1, MMP-10, MMP-11, MMP-14, and MMP-16 and decreased expression of TIMP-3 mRNA (Stamer et al. International Society for Eye Research/BrightFocus Foundation 2nd Glaucoma Symposium, Oct. The gene discussed is TIMP1; the disease is glaucoma.