SLC26A4 and Pendred syndrome: The SLC26A4 variant (p.Val138Ile) that we identified in case R197 is a variant reported to cause Pendred syndrome, an autosomal recessive disorder characterized by vestibular migraines as common comorbidity70 due to enlarged vestibular aqueducts and associated sensorineural dysfunctions.71 Interestingly, a case patient (R197) developed a migraine following minimal trauma and confusion and headache post rugby games, which may have provided a trigger if the patient was vulnerable from a deleterious allele.