Neurotransmitters are disrupted following impact, during seizures and migraines and suppression of the GABA receptor subtype A is linked to post-stroke neuronal damage and ischemic death.63 Potentially pathogenic variants in genes involved in neurotransmitter pathways, GABRG1 and GRIK1, were found in 2 cases in this study. The gene discussed is GRIK1; the disease is migraine disorder.