CACNA1A and migraine disorder: Mutations in CACNA1A demonstrate heterogenous neurological presentations, as exemplified by a family harboring the same mutation with varying symptomology including migraine, hemiplegia, coma, and progressive cerebellar ataxia.50 A novel CANCA1C (p.Ile662Leu) variant was detected in a case patient (R259) presenting with prolonged migraine attacks and photophobia following a minor hit on the head by a ball while playing a sport (netball).