GRIK1 and migraine disorder: In particular, indiscriminate glutamate release leads to increased intracellular Ca2+ following concussion.61 Glutamate is also believed to contribute to secondary injuries through excitotoxicity.66 The GRIK1 gene encodes an N-methyl-D-aspartate (NMDA) receptor and has been implicated in epilepsy-related neurological disorders67 as well as in migraine pathogenesis.68 The latter finding is compatible with the presentation of the case (R171) in which a GRIK1 (p.Asn428Tyr) predicted deleterious variant was identified following the development of a confusional migraine after a minor head injury.