Loss of function mutations in this gene have been implicated in early-onset axonal neuropathy,80 and Charcot-Marie-Tooth autosomal recessive disorder.81 Thompson and colleagues82 demonstrated that TRIM2 ubiquitination of a cell death mediator (Bim/Bcl-2) is one pathway for neuroprotection, and suppressing expression of TRIM2 blocked this ubiquitination and any neuroprotective processes. This evidence concerns the gene TRIM2 and axonal neuropathy.