FGF21 and alkaline phosphatase measurement: In the present study, we showed that damage of mitochondria and lysosomes in pancreatic cells of AP was significantly reduced after treatment with FGF21, and number of autolysosomes increased, suggesting that FGF21 might mediate repair of mitochondria and lysosomal function, promoting lysosome‐induced degradation of autophagosomes and alleviating the damage to autophagy.