Surprisedly, the protective effect of FGF21 in response to cerulein‐induced AP was also prominently weakened in Sirt1‐RNAi‐treated mice (Figure 6E,F), suggesting that the protective effect of FGF21 against acute pancreatic injury by cerulein may be mediated by Sirt1. The gene discussed is FGF21; the disease is alkaline phosphatase measurement.