Similarly to Navitoclax, we observed that Nav‐Gal induces the appearance of annexin V‐positive cells in two models of chemotherapy‐induced senescence, namely cisplatin‐induced senescent A549 lung cancer cells and palbociclib‐induced senescent SK‐Mel‐103 melanoma cells, thereby indicating that senolysis by Nav‐Gal is driven by the implementation of the apoptotic programme. The gene discussed is ANXA5; the disease is melanoma.