The vagal ability to modulate insulin secretion has been confirmed (Gilon & Henquin, 2001), and there is consensus in considering vagal innervation as the part of the nervous system that stimulates ‘rest and digest’ and ‘feed and breed’ processes(Trajkovski & Wollheim, 2016) and is considered to be involved in the development of diet‐induced obesity (Lartigue, 2016). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.