To clarify whether MSA+LBD patients had genetic risk factors for LBD (21, 29), we screened mutations in SNCA (p.A30P and p.A53T), LRRK2 (p.G2019S), and VPS35 (p.D620N), as well as copy number of SNCA; however, all patients had a wild type and had normal copy number of SNCA. We also screened risk variants of GBA and found that two patients with MSA+LBD had the variants: p.T408M in Case 4 and p.E365K in Case 10. This evidence concerns the gene GBA1 and multiple system atrophy.