PRNP and variant Creutzfeldt-Jakob disease: A highly characteristic feature of vCJD is the accumulation of abnormal prion protein (abnormal PrP, or also designated PrPSc), a misfolded form of the normal host prion protein (PrPC) [2] in the lymphoreticular system, such as lymph nodes, tonsils, spleen and lymphoid follicles in intestinal organs [19, 21, 24], something that is absent in sporadic CJD [19, 21], or other transmitted forms such as kuru [6, 10] or iatrogenic CJD [18].