The abnormal accumulation of PrP in lymphoid tissue, as detected by immunohistochemistry, has only ever been found in humans with vCJD, and not in other human prion diseases such as sCJD [19, 20], and the transmitted forms of iatrogenic CJD [18] or Kuru [6, 10]. The gene discussed is PRNP; the disease is Creutzfeldt Jacob disease.